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Research in the IDM is led by over 34 independent principal investigators in the basic, clinical and public health sciences, and has a strong translational focus.

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Grant and contract funding is sourced from the US National Institutes harga poco x3 gt 8/256 Health, the Bill & Melinda Gates Foundation, The Wellcome Trust, EDCTP, the South African Medical Research Council, the National Research Foundation of South Africa, the Technology Innovation Agency, and many other agencies.

IDM Members and their groups contribute significantly to the research outputs of the Faculties of Health Sciences and Science at UCT. Kindly refer to our research highlights for more information.

Multi-investigator groups: • The South African TB Vaccine Initiative (SATVI) • The Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) • The Desmond Tutu HIV Centre (DTHC) Extramural research units of the South African Medical Research Council ( SA MRC): • Drug discovery and Development Research Unit (H3D) • Molecular Mycobateriology Research Unit (MMRU) • Precision and Genomic Medicine Research Unit (PGM) SA MRC Collaborating Centres: • Clinical and Community HIV-Tuberculosis Research Collaborating Centre • Centre for Tuberculosis Biomarker-Targeted Intervention Other research entities: • AFGrica • Computational Biology (CBIO) • Biopharming Research Unit (BRU) • DSI/NRF Centre of Excellence for Biomedical TB Research (CBTBR) • Vaccines for Africa (VACFA) Affiliate membership is for researchers based at UCT, elsewhere than in the IDM complex, who seek supplementary membership of the IDM because their research interests align with the general focus and current activity areas of the IDM, for 3-year terms, which are renewable.

BOULLE, Prof Andrew MBChB, MSc, PhD, FCPHM(SA). Division of Public Health Medicine and Centre for Infectious Disease Epidemiology and Research (CIDER), School of Public Health and Family Medicine; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine; Health Impact Assessment directorate, Department of Health, Provincial Government of the Western Cape.

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Research interests: HIV cohort and infectious disease epidemiology; operations research on service responses for priority health conditions; data harmonisation and linkage; and context-appropriate health information systems development. DHEDA, Prof Keertan Keertan Dheda (MBBCh (Wits), FCP (SA), FCCP, PhD (Lond)) is Head of the Lung Infection and Immunity Unit and Associate Professor of Respiratory Medicine (SARChI), Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town.

He holds an honorary faculty position at UCL. His group’s main research interests are the study of pulmonary regulatory immunological pathways in relation to infection, rapid and field-friendly diagnosis of tuberculosis, and drug-resistant tuberculosis.

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His work is funded by the SA MRC, SA NRF, EU FP7, EDCTP and NIH. EGAN, Prof Timothy PhD (Bioinorganic Chemistry), Head of Department and Jamison Professor of Inorganic Chemistry, Science Faculty, UCT. Research interests: understanding how the malaria parasite deals with the large influx of haem associated with ingestion and degradation of haemoglobin in its digestive vacuole and the effects of antimalarials such as chloroquine, which inhibit this process.

Biomimetic investigations of β-haematin (synthetic haemozoin/malaria pigment) formation.

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Speciation and behaviour of free Fe(III) haem in aqueous solution. Interaction of Fe(III) haem with antimalarials and effects on haem in cultured parasites.

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Synthesis and structure-activity relationship studies on β-haematin inhibiting compounds. JOSEPH DAVEY, Dr Dvora BA, MPH, PhD (Epidemiology). Honorary Senior Lecturer, School of Public Health and Family Medicine, Division of Epidemiology and Biostatistics, Desmond Tutu Health Foundation.

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Dvora is an Assistant Professor of Epidemiology at the University of California, Los Angeles. Her research focuses on evaluating innovative technologies and interventions to improve the delivery of HIV/STI prevention interventions (including pre-exposure prophylaxis) and treatment in sub-Saharan Africa, especially in pregnant women, male partners and families.

MAARTENS, Prof Gary MBChB, MMed, FCP SA DTM&H; Head of the Division of Clinical Pharmacology His main research interests are in the therapeutic aspects of HIV-associated tuberculosis and drug-resistant tuberculosis, antiretroviral therapy in resource-limited settings, and the pharmacokinetics of antiretroviral and anti-tuberculosis drugs.

McILLERON, Prof Helen MBChB(UCT), PhD in Clinical Pharmacology, Department of Medicine, University of Cape Town.

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Key research areas involve optimising doses and drug combinations for patients with drug-resistant tuberculosis or TB/HIV co-infection, and optimising anti-tuberculosis drug use in children. She participates in research projects across Africa, as well as in Asia and South America where a key interest is the support and mentoring of investigator-initiated pharmacology research projects. MYER, Prof Landon MBChB MA MPhil PhD; Professor, Centre for Infectious Diseases Epidemiology & Research, School of Public Health & Family Medicine Thirty-one Masters students supervised; broad areas of research are: epidemiology of HIV/AIDS, other sexually transmitted infections & tuberculosis; maternal and child health; women's reproductive health.

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NTSEKHE, Prof Mpiko BA, MD, MPhil (Cardiol), PhD, FCP (SA), Cert Cardiol (SA), F.A.C.C. Helen and Morris Maueberger Professor and Chair of Cardiology, Department of Medicine, University of Cape Town and Head: Division of Cardiology Groote Schuur Hospital.

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Ongoing research: Investigation of the Management of Pericarditis (IMPI), Inflammatory determinants of disease severity and treatment outcome in TB patients, Left Cardiac Sympathetic Denervation for Cardiomyopathy Pilot Study, HIV Associated Myocardial Fibrosis Study.

SLIWA-HAHNLE, Prof Karen Director, Hatter Institute for Cardiology Research; Diploma in Tropical Medicine and Hygiene, specialist physician, cardiologist (2000). Is one of the very rare cardiologists in South Africa who is clinically active and trained in fundamental molecular laboratory methods, combining laboratory and epidemiological skills. Widely published in both local and international journals and books of various topics related to cardiovascular medicine.

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Internationally recognized for her outstanding work in the area of heart failure. Collaborations with a range of prestigious national and international clinical and academic centers. She holds an appointment as adjunct professor at the University of Queensland, Brisbane, Australia and as a visiting professor at the Baker Institute in Melbourne, Australia.

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STEIN, Prof Dan Professor and Head of Dept, Psychiatry and Mental Health; Chair in Psychiatry; Director, the Brain and Behaviour Initiative (BBI). The Brain and Behaviour Initiative (BBI) enables cross-faculty, multidisciplinary, collaborative research in the cognitive and affective neurosciences and brings together expertise on phenotyping, genotyping, cognotyping, brain imaging and molecular signatures to address brain-behaviour issues.

New experimental techniques including brain imaging, genetic testing and neuropsychological assessment combined with new theoretical insights have opened up significant potential for the advancement of novel diagnostic tools and treatments for people with mental disorders. The initial focus on trauma and resilience has now extended to work in substance use and NeuroHIV. ZAR, Prof Heather MBBCh, FAAP, PhD is head of Paediatric Pulmonology at Red Cross Childrens Hospital, University of Cape Town.

Her research focuses on child lung health including HIV-associated lung disease, childhood pneumonia and childhood TB. Harga poco x3 gt 8/256 2014 she received the 2014 World Lung Health Award, awarded by the American Thoracic Society at a ceremony in San Diego, in recognition of work that has "the potential to eliminate gender, racial, ethnic, or economic health disparities worldwide".

ZÜHLKE, Assoc Prof Liesl MBChB, DCH, MPH, PhD(Cape Town) FC Paeds, FESC, FACC. Paediatrician/Paediatric Cardiologist, Department of Paediatric Cardiology, Red Cross War Memorial Children’s Hospital; Director and Medical Specialist, Children’s Heart Disease Research Unit, UCT. Currently regarded as a thought leader in Rheumatic Heart Disease, both on the continent and internationally.

Has significant international research collaborations within the Rheumatic Heart Disease Community and within the Cardiovascular Community. Her social responsibility is reflected in, amongst others, numerous board positions; and she continues to be involved in teaching, training and mentorship encompassing courses directed at nurse practitioners, clinical officers and echocardiography masterclasses in South Africa, Ethiopia, Zambia and Uganda.

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