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INSTITUTIONAL RESEARCH COMMITTEE, IDM: INTERNAL PROTOCOL FOR • FINANCIAL REVIEW OF IDM RESEARCH PROPOSALS AND • STUDY PROTOCOLS REQUIRING ETHICS APPROVAL eRA pre-awards approval process The Pre-awards section of the electronic Research Administration (eRA) system was created to streamline and standardise UCT’s current grant application and submission processes. This process helps to manage risk (in terms of resource use, research ethics, health and safety, and finances) to both the PI and the university and serves to support internal application review to ensure all information required by the funder is complete upon submission.

All new protocols applying for external funding must follow the proposal approval process via the eRA Pre-awards module.

If there was no specific funding call and the process was initiated by contract negotiation with the funder/sponsor or if a proposal approval form was submitted harga nail polish ms glow the time of application, but the funder requests changes to the project or budget at award/contract stage then PIs must follow the contract approval process.

Applications for NRF, URC, and SAMRC self-initiated research grants are not required to follow the eRA Pre-awards approval process but still require liaising with the Central Finance and Research offices directly. If in doubt as to when an approval form should be submitted, ask yourself: will what I am submitting pose any potential risk to UCT, whether in terms of resource use, research ethics, health & safety, and finances?

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If the answer is yes, then complete a pre-awards approval form. For further information visit the pre-awards FAQ page.

Pre-awards internal approval process • Visit UCT’s Research Portal and log in to the eRA system using the Login option at the top right-hand corner of the screen. • Under the ”Add New Content” button in the top right corner of your Dashboard select “Project Application/Approval Request” ? • Under the “Other Funding Schemes” menu, choose “Application stage approvals” or “Contract stage approvals” and select relevant form type (Preliminary Proposal Approval / Proposal Approval / Contract Approval) • The PI uploads the requested project documents and captures key project information and details relating to resourcing, ethics, and biosafety online.

• The form is sent online to Departmental Research Finance Staff ( Budget Reviewer) to complete project-related finance information that was discussed with the PI prior to submission of the form. • When the Budget Reviewer has completed the Financial Information, the form will be returned to the PI for review of the financial details.

• The PI confirms their agreement with this financial information and sends the form to the Finance Approver step. • Internal review and approvals are then completed by relevant Faculty Finance and Deanery ( Final Faculty Approver) staff. • Completion of internal approval through the eRA system will deem your application ready for submission by the institution (or PI) to the funder or for sign off of the research contract.

Importantly for proposals, please note, your application is not submitted to the funder via the eRA system. If UCT is required to authorise submission of your application to a funder, it is advised that the PI contacts Research Contracts and Innovation (RC&I) once internal Faculty approval is complete to confirm expectations of when their review would be complete, and which documents require a signature to proceed to submission to the funder.

A) FINANCIAL REVIEW The University's Pre-Awards process must strictly be adhered to. Submission of the eRA pre-awards approval form via the eRA portal needs to be assigned to the Assistant Research Management Accountant, Joy Joachims (extension 1582) who will reassign to one of the pre-award team members based on workload and / capacity. The Budget Reviewer will complete the “Financial Information” tab within the eRA approval form for all external grants and drug trial funding following review of the budget.

The Budget Reviewer should return the supported financial information within 3 working days of receipt of the approval form, harga nail polish ms glow only if IDM Finance assistance was sought and engaged prior to logging the application onto the eRA portal.

The advantages of contacting the Budget Reviewer timeously are: • Budgets will be in line with UCT Finance Policies and Procedures. • Budgets are fully or appropriately costed [if the grant is awarded, no further re-negotiation with funders is required as is often the case at present].

• VAT implications are correctly incorporated, as the VAT Apportionment ruling has changed how much Input VAT can be claimed on purchases.

• IP protocols are followed with regard to financial implications. • There is no delay in the final contract process. • UCT will sign a grant contract sooner compared to harga nail polish ms glow finances were still to be signed off after the grant is awarded. Current exceptions for eRA pre-awards approval process National Research Foundation (NRF): Step 1: Applicants who submit applications by the internal closing deadline are guaranteed an internal review. Step 2: Internal review is undertaken by the Research Office.

In rare but necessary cases harga nail polish ms glow Thuthuka, CPRR, and CSUR – scientific reviews are also undertaken by discipline experts. Step 3: Feedback is provided to applicants and, if necessary, applications reopened for amendment.

Step 4: Applicants resubmit applications before the NRF final deadline. Cancer Association of South Africa (CANSA) & Poliomyelitis Research Foundation (PRF) – for Health Sciences researchers: To apply, researchers email their completed application form to the funder and copy an administrator in the Faculty of Health Sciences Dean’s Office. The administrator will obtain institutional approval from the Deputy Dean for Research and forward this to the funder.

South African Medical Research Council (SAMRC): For the SAMRC Self-Initiated Research (SIR) grant scheme, researchers complete an online application form and press submit. The application then gets sent to an internal administrator in the Faculty of Health Sciences who takes the application to the Deputy Dean for Research for institutional approval.

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Once the signed application is received, the administrator uploads this and completes the online submission to the funder. B) For all study protocols that require Faculty Human or Animal Research Ethics Committee clearance Two standing subcommittees of the IRC will be responsible for the scientific review of protocols requiring human or animal ethics clearance.

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The two standing subcommittees of the IRC namely the Human Research Scientific Review and the Animal Research Scientific Review subcommittees will be responsible for establishing an explicit and formal scientific review process that evaluates the scientific merit and potential risks of each protocol before the protocol is submitted to Harga nail polish ms glow Human or Animal Research Ethics Committees.

Dr Keren Middelkoop and A/Professor Suraj Parihar chair the subcommittees respectively, and each subcommittee is made up of members drawn from within the IDM and UCT with relevant background and experience. Send an electronic copy of the application (to Andruween Kadalie (ext 6098) including names of two potential and suitably qualified researchers/reviewers affiliated to or within the IDM and UCT but who are not collaborators.

Andruween in turn will log the application with a tracking number. Hardcopies will be requested only once the relevant IRC subcommittee has approved the application. For protocols requiring human scientific reviews, the following materials are to be submitted: • FHS013 • Protocol • Synopsis • Consent and assent documents • Original protocol if a sub-study • Any other relevant appendices If your protocol is a sub-study of an existing study, please include a brief description of the parent study, the current status of the parent study, and how the sub-study will fit with the parent study.

Andruween will forward the proposal electronically to the subcommittee Chair who in turn assigns the proposal to a member of the subcommittee as primary reviewer. The secondary reviewer will be assigned by the subcommittee member and will be drawn from the names of potential reviewers as per applicant's recommendation Protocols to be reviewed within one week.

Comments of primary and secondary reviewers will be sent to all members of the harga nail polish ms glow subcommittee. Each subcommittee will meet and consider all reviews. Hardcopies of approved proposals will be requested and signed on the same day. A report will be sent to the applicant within 24 hours to give the applicant the opportunity to respond and/or revise their application if the proposal requires revision.

The applicant will thus have approximately three days to re-submit to the subcommittee Chair, prior to the HREC and AREC deadlines. Approval of resubmissions is however at the discretion of the subcommittee Chairs and outstanding or major issues may be held over to the next subcommittee meeting. Due Dates for submission of applications for 2022 Scientific and Ethics reviews are listed here.

Andruween Kadalie services the Subcommittees.

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PLEASE ALSO NOTE : The IRC Committees will not normally review Grant applications unless a complete protocol is submitted for review. Protocols that are the result of successful grant awards following the C1 process, and that have already undergone scientific review, will only be re-reviewed by the IRC if substantive changes to the study design have taken place.

Mechanisms are in place to deal with urgent applications. Please notify either Keren Middelkoop or Jo-Ann Passmore, and Assistant Research Management Accountant Joy Joachim well in advance of a looming deadline should this be anticipated, so that the necessary arrangements can be made to expedite the approval process. Resubmission of amended proposals to AERC require the Animal Research Scientific Committee Chair and IDM Director signatures. An additional column has been added to accommodate due dates for required signatures.

Eligibility Criteria for IRC Expedited Review: • Protocol submitted outside the published submission-review cycle for which there is reasonable confidence that UCTHREC will also offer expedited review. 'Reasonable confidence' would in almost all instances need the investigator to approach the UCTHREC Chair for harga nail polish ms glow.

• Protocol involving minimal complexity, for example: establishment of biobanks or databases; some laboratory studies using previously stored samples. • IDM/UCT involvement is a minor component of an external study, for example: laboratory analysis of non-endpoint assays for samples collected at non-UCT sites. • Protocol is a sub-study of a previously IRC and UCTHREC reviewed and approved protocol that is carried out in the same study population with expansion of the same aims and interventions.

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Introduction Subaru's EE20 engine was a 2.0-litre horizontally-opposed (or 'boxer') four-cylinder turbo-diesel engine. For Australia, the EE20 diesel engine was first offered in the Subaru BR Outback in 2009 and subsequently powered the Subaru SH Forester, SJ Forester and BS Outback.

The EE20 diesel engine underwent substantial changes in 2014 to comply with Euro 6 emissions standards – these changes are discussed below and summarised under ‘Euro 6 changes’. Please note that this article considers the EE20 engine as it was supplied in Australian-delivered vehicles. As such, it does not consider the Euro 4 emissions compliant EE20 engines that were available in Europe. Furthermore, specifications for other markets may differ from those in Australia.

The EE20 engine was manufactured on the same assembly line as Subaru's six-cylinder horizontally opposed petrol engines at its Oizumi factory. Subaru EE20 diesel engine Model Engine Trans. Power Torque Years C.R. Euro Subaru BR Outback 2.0-litre turbo-diesel F4 6sp man. 110kW at 3600rpm 350Nm at 1800-2400rpm 2009-13 16.0:1 Euro 5 350Nm at 1600-2400rpm 2013-14 CVT 110kW at 3600rpm 350Nm at 1800-2400rpm 2013-14 16.3:1 Subaru SH Harga nail polish ms glow 2.0-litre turbo-diesel F4 6sp man.

108kW at 3600rpm 350Nm at 1800-2400rpm 2010-12 16.3:1 Euro 5 Subaru SJ.I Forester 2.0-litre turbo-diesel F4 6sp man. 108kW at 3600rpm 350Nm at 1600-2400rpm 2013-15 16.0:1 Euro 5 Subaru SJ.II Forester 2.0-litre turbo-diesel F4 6sp man. 108kW at 3600rpm 350Nm at 1600-2400rpm 2015-on 15.2:1 Euro 6 Subaru BS Outback 2.0-litre turbo-diesel F4 6sp man., 6sp CVT 110kW at 3600rpm 350Nm at 1600-2800rpm 2014-on 15.2:1 Euro 6 EE20 block The EE20 engine had an aluminium alloy block with 86.0 mm bores and an 86.0 mm stroke for a capacity of 1998 cc.

For its Euro 4 and Euro 5 versions, the EE20 engine had a semi-closed block (i.e. the cylinders bores were attached to the outer case at the 12, 3, 6 and 9 o’clock positions) for greater rigidity around the head gasket.

For the Euro 6 EE20 engine, however, an open deck design was adopted which eliminated the 12 and 6 o’clock supports.

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For the EE20 engine, all five main bearings in the cylinder block had metal matrix composite journals (inserted during the cast process) for rigidity and due to their similar thermal expansion to the crankshaft. Furthermore, cooling slits between the cylinder bores provided water cooling channels. For comparative purposes, dimensions of Subaru’s EE20, EJ20 and EZ30 engines are given in the table below. EE20 EJ20 EZ30 Engine type Diesel F4 Petrol F4 Harga nail polish ms glow F6 Displacement (cc) 1998 1994 2999 Bore x stroke (mm) 86.0 x 86.0 92.0 x 75.0 89.2 x 80.0 Bore pitch (mm) 98.4 113.0 98.4 Bank offset (mm) 46.8 54.5 46.8 Deck height (mm) 220 201 202 Journal diameter (mm) 67 60 64 Crankpin diameter (mm) 55 52 50 Effective length of connecting rod (mm) 134.0 130.5 131.7 Piston pin diameter (mm) 31 23 22 Compression height (mm) 43.0 33.5 30.0 Engine length (mm) 353.5 414.8 438.4 Crankshaft, connecting rods and pistons To withstand the high combustion pressures of a diesel engine, the crankshaft for the EE20 engine was subjected to a surface treatment for increased strength.

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Furthermore, the crankshaft journals were made from aluminium and cast iron due to the high pressure applied on both side of the cylinder block. The forged connecting rods had fracture split bearings for the crank end and an asymmetrical profile which increased precision during assembly. The pistons had internal cooling channels, while oil jets in the crankcase sprayed the underside of the pistons.

Cylinder head The EE20 engine had an aluminium alloy cylinder head that was 17 mm thinner than the EJ20 engine. Furthermore, the intake ports and the diameter of the intake valves were designed to create a swirling effect for the air as it entered the combustion chamber. The EE20 engine had double overhead camshafts (DOHC) per cylinder bank that were driven by a chain and gear with a speed-reducing gear.

The four valves per cylinder (two intake and two exhaust) were actuated by pivot-type roller rocker arms. IHI turbocharger The EE20 engines have IHI turbochargers with variable nozzle turbines (VNTs).

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Generally, VNTs use movable vanes in the turbine housing to adjust the air-flow to the turbine to realise comparable exhaust gas velocity and back pressure throughout the engine’s rev range. To enhance torque at engine speeds below 1800 rpm, the nozzle vanes would close to narrow the air path and increase the speed of the air flow.

At higher engine speeds, however, the vanes would open to reduce airflow resistance and improve fuel consumption.

Initially, the turbocharger was positioned under the engine. For the Euro 6 EE20 engine, it is understood that the turbocharger was relocated to the bottom right of the engine.

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It is understood that the maximum turbine speed for the IHI turbochargers used in the EE20 engine is 190,000 rpm. Injection and combustion The Euro 4 and Euro 5 EE20 diesel engines had a Denso common-rail injection system with eight-hole, solenoid-type injectors that achieved an injection pressure of 180 MPa. For the Euro 6 EE20 engine, however, injection pressure was increased to 200 MPa.

For the EE20 engine, the injectors were positioned at an almost 90 degree angle to the cylinder and were 40-50 mm shorter than those used in inline four-cylinder diesel engines.

The Euro 5 and Euro 6 EE20 engines are understood to have ceramic-type glow plugs. EGR and DPF The EE20 diesel engine had a water-cooled exhaust gas recirculation (EGR) system which recirculated exhaust gases to the intake to lower combustion temperatures and reduce NOx emissions.

The Euro 5 and Euro 6 EE20 engines had a closed-loop diesel particulate filter (DPF); both the oxidation catalyst and DPF were positioned next to the turbocharger to utilise the heat of the exhaust air.

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Euro 6 changes The Euro 6 emissions compliant EE20 diesel engine was introduced in the Subaru BS Outback in 2014 and the Subaru SJ.II Forester in 2015. Relative to the Euro 5 version, changes for the Euro 6 EE20 engine included: • An open deck cylinder block; • An increase in piston crown capacity; • A new piston skirt coating was introduced to reduce friction; • A reduction harga nail polish ms glow the compression ratio to 15.2:1 to lower combustion harga nail polish ms glow and reduce NOx emissions; • A fourth generation common rail injection system was introduced for higher injection pressure (200 MPa, previously 180 MPa) and a finer fuel spray; • Each diesel injector had an integrated driver unit to reduce fuel leak volume, fuel pump load and improve fuel economy; • A low-friction timing chain was introduced to drive the fuel pump (previously gear-driven) for quieter operation; • The glow plugs were revised to improve pre-heating temperature at start-up and increase after-glow time; • Oil jets were added to the timing chain drive; • A low-pressure EGR circuit was introduced to increase the EGR rate, while the high-pressure EGR circuit was ‘optimised’; • The turbocharger repositioned at the bottom right of the engine (previously under the engine) and improved vane control was achieved; • The diesel particulate filter (DPF) substrate specifications were revised and regeneration performance enhanced.

The type and amount of precious metals in the oxidation catalyser and DPF catalyst were also revised; • The number of idlers used in the auxiliary belt system was reduced; • A more precise sensor measured battery current, voltage and temperature; and, • The rear flange and bracket material, exhaust pipe and end plate material were changed for rust prevention.

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